Progenesis LC-MS - identify the real differences in your proteomics data...

Progenesis LC-MS is an advanced proteomics research solution for your label-free quantitative analysis using unique technology to deliver the advantages of speed, objectivity and statistical power. It applies simple workflows so you can easily visualise complex analysis data, quickly gain confidence in results and generate reliable conclusions for your research. Contact us to get a demonstration of Progenesis LC-MS analysing your own data.

• Speed - Intelligent peak modelling and data reduction enables the analysis of more data, more rapidly. Fast alignment and processing means you can quickly focus your MS-MS identification. The streamlined workflow gets you robust and reliable results in less time, allowing you to maximise the efficiency of your research.



• Objectivity - The guided workflow and highly automated analysis process promotes a consistent approach making it possible to reproduce experiments within and across-labs.



• Statistics - Multivariate statistics allow you to visualise and explore relationships within your complex biological data. This analysis workflow provides high quality and complete datasets so your multivariate statistical analysis is reliable and robust.

        

Progenesis LC-MS v1.1 - unique analysis workflow

Quality Control - Automatic quality control assessment and feedback at the start of your workflow highlights potential issues.

Data Alignment - The advanced data alignment uses a unique but easy to use, interactive approach. Powerful visual tools allow accurate assessment of the automatic alignment.

    

Label Free Detection & Quantification - A single peptide map is created containing all the peptides from all samples so they can be detected and quantified. The advanced detection algorithm handles complex samples and overlapping peptides, while accurate quantitation and normalisation enables confident differential analysis. The fully automatic analysis process produces high quality and complete datasets that allow robust, statistical analysis with multivariate statistical tools.

Experimental Group Setup - Multiple experiment groupings (e.g. male v female, control v treated) can be defined making it quick and easy to ask numerous questions of your data.

Peptide Selection - Significant peptides are ranked for review by fold-change and ANOVA (p-value). Each peptide can be assessed using the 1D / 2D/ 3D views and expression profiles. Any editing of detected peptides is greatly simplified as a single edit on the peptide map is propagated across all samples. Peptides can be grouped in multiple ways using the simple yet powerful tags feature which allows the exploration of complex relationships. Peptides of interest are sent to an inclusion list or taken forward for multivariate statistical analysis and MS-MS identification.

Progenesis Stats - An advanced, easy-to-use multivariate statistical analysis tool for confident data exploration and visualisation. This allows False Discovery Control, Principal Components Analysis, Correlation Analysis and Power Analysis to be performed on your data.

Search MS-MS Protein Identification Database - Visual tools assist with the validation and selection of MS-MS spectra for protein database search. You can then export a search query to Mascot (Matrix Science), SEQUEST (Thermo Fisher Scientific Inc.) or Phenyx (GeneBio) software for the identification and characterization of proteins and peptides.

Import Protein Data & Report - Imported search results are displayed alongside the full analysis results. A simple, customisable report provides an overview of the peptides which were selected for further investigation and includes any MS-MS protein identification results.

Contact us to get a demonstration of Progenesis LC-MS analysing your own data.