Progenesis overcomes the challenge of cross-lab reproducibility for proteomics
Progenesis SameSpots helps you overcome the biggest challenge facing everyone in quantitative proteomics today, cross-lab reproducibility of results. If you can achieve this then you can be confident in measuring real biological effects that can make a difference, not just reporting artefacts of an experimental approach. Progenesis LC-MS applies a similar unique approach so we hope it can show the same benefits and cross-lab reproducibility with your quantitative MS proteomics analysis.
The HUPO Reproducibility Study
Results from the groundbreaking HUPO Reproducibility Study, which used standard protocols and Progenesis SameSpots, prove that protein expression analysis is reproducible across-labs and highly reproducible within-lab. A publication is in-progress but some of the initial data1, 2 are represented below. You can read full details and see the poster of results presented at HUPO 2008 and the 8th Siena Meeting 2008.
How does Progenesis achieve this?
The unique Progenesis workflow perfectly aligns data prior to analysis allowing all detected features to be 100% matched and compared directly across every run without the need to validate or edit each individual feature. This means you can quickly see the real expression differences without laborious, subjective editing and make valid conclusions using multivariate statistics applied to a complete data set.
The algorithms and workflow have been specifically applied for 2D and LC-MS data analysis with Progenesis SameSpots and Progenesis LC-MS. So whichever proteomics technique you run the result is always rapid unbiased analysis and high quality data for publication.