What instrument types, data types and file formats are supported?
Progenesis CoMet works with a wide variety of machine types. For most instrument types, the default ion detection method in Progenesis CoMet should be used. For low resolution ion trap instruments, the specialised low resolution detection method option should be used. We have also included an option for optimum detection of runs from Thermo FT-ICR instruments, which typically has much lower levels of noise than data from other instrument types.
Data may be in either profile or centroided forms, although you will usually get better results using profile data. Additionally, if you use centroided data you will be asked to enter the full width at half maximum (FWHM) resolution of the machine on which the data was collected.
Progenesis CoMet directly supports many of the most common data formats produced by mass-spec machines. It also offers an extension mechanism by which new formats can be supported (see the custom development section below).
The following list gives the various file formats currently supported, both those that are pre-packaged with the software and others that can be downloaded to extend your existing software:
- Waters (MassLynx) .RAW folders (with dead time correction)
- Thermo (Xcalibur) .RAW files
- Agilent (MassHunter) .d folders
- Bruker Daltonics .d folders
- NetCdf .cdf files
Currently, other formats should be converted to mzXml. For example:
- ABI wiff files may be converted using msconvert.exe from ProteoWizard.
We're happy to work with you to support other file formats you may prefer to use. If you're interested in this option, please email firstname.lastname@example.org and one of our development team will contact you to discuss your needs and how we might help.