Progenesis CoMet analyses LC-MS and GC-MS data to discover and reliably quantify compounds and metabolites that are significantly changing in your samples.

Key benefits

Using Progenesis CoMet, you’ll benefit from:

• streamlined quantification and identification
• accurate peak picking
• complete data with no missing values
• quantification of compounds
• summary of interesting quantified and identified compounds
• support for major hardware vendors

A comprehensive and streamlined workflow

Progenesis CoMet has been developed to measure the relative abundances of metabolites through the analysis of LC-MS or GC-MS data.

It was developed in response to feedback from metabolomics researchers that their analysis involved jumping between many different applications, some developed in-house, to get a final result. This workflow has been streamlined with straightforward analysis steps for quantification and support for the integration of metabolomics database search results.

Peak picking that accurately detects compound ions in complex samples

We have developed a bespoke peak picking algorithm to discern compound ions in complex samples. It can detect and differentiate overlapping compound ions which helps generate accurate quantification data.

Complete data with no missing values

Accurate retention time alignment, so all compound ions are in the same location, and co-detection across all sample runs produces a complete data set with all sample runs containing the same number of compound ions. With no missing values, valid multivariate statistical analysis can be applied.

Highly accurate quantification of compounds

Progenesis CoMet provides precise measurements of your compound ions based on the ion intensities. You can find the compound ions which have statistically significant abundance changes across groups and export their data to your database for identification purposes. When you have imported and reviewed the search results you end up with a single measurement per identified compound.

Summary of the interesting compounds for further study

When you have worked through the steps of the analysis workflow you conclude with a table of identified compounds. Using the tags feature, which groups compounds by a specific characteristic, you can narrow down the final compound list.

Support for all major machine vendors

We support data from Thermo, Bruker and Waters instruments in Progenesis CoMet. We also support cross-vendor file formats (e.g. mzXML) so we are platform independent. See our Instrument Types FAQ for more information.

If your instrument or file format isn't supported yet, contact us and we'll see what we can do to help.

Want to learn more?

For more information on Progenesis CoMet and its approach to data analysis, please see the following:

• How Progenesis CoMet works: an overview of how analysis is performed, focussing on the most important technical details that differentiate Progenesis from other software
• Frequently-asked questions: answers to many of the most common questions we're asked

Finally, if you have any questions that are not covered by these pages, please ask us a question. We aim to respond to all enquiries within 1 working day.